Laboratory Test Directory



Alpha-Fetoprotein Triple Marker Screen, 2.0 MoM
Methodology:Immunoassay Calculation Immunochromatographic Membrane Assay
Performed:3-5 days
Reported:"Collect: Serum Separation Tube (SST) - 1.5 ml serum. 

INSTRUCTIONS: Collect specimen between 14-22 weeks gestation. Icteric or Grossly lipemic specimens are not acceptable. Split serum into two tubes and ship on cold pack. If not shipped immediately, samples should be frozen. SPECIAL INSTRUCTIONS: Must include: Gestational age, LMP, Weight, Race, Insulin dependent, number of fetuses, and initial or repeat screen. NOTE: Reject criteria: Grossly lipemic 
The performance of this test varies with maternal age and other clinical parameters. Ongoing research suggests that approximately 60% of Down syndrome (DS) pregnancies and 60% of trisomy 18 pregnancies can be detected. This use is considered to be investigational. Follow-up testing is recommended for patients when the calculated second trimester risk of Down syndrome risk is 1 in 270 or greater. Normal serum AFP levels for neural tube defects (NTD) are less than 2.0 multiples of the median (MoM). Normal values exclude approximately 95% of cases of anencephaly, 80% of cases of spina bifida, and 85% of ventral wall defects. Closed dysraphic states and small defects generally constitute the group in which total exclusion is not possible.
COMMENT: TMS fails to detect about 30% of DS cases in women 35 years old and 10% in those 40 years old, as well as approximately 30% of trisomy 18 and 50% of other chromosomal abnormalities. CVS or amniocentesis is the test recommended by the American College of Medical Genetics for women over 35 years old. 
Storage/Transport Temperature: Refrigerated 
Stability: Room Temperature/Refrigerated: 1 week; Frozen : 1 month 

Note: This test is approved for NY . 

Performing Lab 
Quest Diagnostics Nichols INST
Specimen Required:82105, 82677, 84702
CPT Code(s):Sun-Sat
Test Panel Componenets:AFP: AFP MoM: < 2.00 MoM; uE3 (unconjugated Estriol): uE3 (unconjugated Estriol) MoM: hCG: hCG MoM: Down Syndrome Risk: DOWN SYNDROME SCREEN: Down Syndrome Interpretation: Open Spina Bifida Risk: OPEN SPINA BIFIDA SCREEN: Open Spina Bifida Interpretation: TRISOMY 18 SCREEN: Comments: Method of Estimation: Number of Fetuses: Weeks Gestation: Race: Weight: Insulin Dependant Diabetes: Date of Ultrasound: Date of LMP: Date of Birth:

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